Short-Term Application Of Intravenous Amino Acids For The Control Of Cravings And Withdrawal

Addiction and substance abuse is undermining the very moral fabric and future of America today. In 1995 it was estimated that the cost of alcohol and other drugs reached a staggering figure of 276 billion, not including the pain and suffering of loved ones and friends. Alcoholics have an estimated decrease in life expectancy of 10-15 years, with alcohol the most frequently used and abused intoxicant and involved in 40% of all fatal motor vehicle accidents (1 and 2).

Although not illegal, nicotine accounts for approximately 25 million people addicted and is the cause of 430,000 tobacco related deaths per year.

The most commonly abused opiates are, heroin and methadone. It has been estimated by the National Institute of Drug Abuse that approximately 2.5 million Americans have a history of heroin abuse (3).

Stimulants such as cocaine are widespread as well in America and it is estimated 72 million Americans have tried or are using or cocaine (3).

Methamphetamine is growing at an unstoppable rate due to the ease of making the drug, and is now competing with cocaine as a drug of choice.

Although there are numerous examples of addictive drugs in America they all show similar symptoms and qualities of craving and withdrawal conditions. The individuals at greatest risk are genetically predisposed through a neurochemical pathway that alters the minds perception of pleasure and reward. Kenneth Blum, coined the term, “Reward Deficiency Syndrome,” to relate to the neurotransmitter deficit that occurs due to use of drugs and alcohol. Although the pathways may vary, depending on the abused substance, they all show a common final neurochemical pathway in their expression of euphoria when abundant, and craving when deficient.

The important Amino-peptide neurotransmitters to date are serotonin, dopamine, GABA and the enkephalins. Dopamine specifically is the neurotransmitter of pleasure. When dopamine is in abundance, it provides a state of well-being. Although this research will focus on alcohol, there are many other substances that can alter the increase in dopamine resulting in pleasure. Other altering scenarios can be glucose, impulsive/compulsive disorders, gambling and risk-taking activities, opiates, cocaine and cigarettes.

When the brain is supplied with a substance a momentary spike in neurotransmitter activity of dopamine occurs. The body then reacts to down regulate this excessive increase by down regulating the neurotransmitter sites of production or receptor sites, or by increasing the breakdown of neurotransmitters. Because of this, the brain develops tolerance and the need for more of the drug to prevent a state of withdrawal.

The point at which addiction can occur is variable and based on the individual’s genes. Recently, the dopamine D2 receptor called the A1allele, has been known to be a greater prevalence for alcoholics, opiate or cocaine addicts.

This pleasure and reward system was discovered, by accident, in 1954 by James Otis. By mistake, Otis placed electrodes in the Para limbic system of rats. In doing so, Otis observed he could elicit a pleasure response. This response caused the rats to continuously press a lever, causing an electrical stimulation to this area even to the point of starvation. It was later noted that an increase in dopamine was being released in regions of the limbic system, specifically the nucleus accumbens and the hippocampus.

Recently, a pharmacological approach to alter these neurotransmitters and help people with reward deficiency syndrome has been found. Studies by Brown and Blum indicate that certain amino acid precursors can relieve cravings and reduce incidents of a relapse. Oral formulas have been formulated and produced with these amino acids, vitamins and minerals cofactors. Recently an intravenous pharmacological approach utilizing amino acid neurotransmitter precursors have shown to have an immediate and profound effect on craving reduction and withdrawals in 86% of the patients with no side effects noted by this researcher or by Excel treatment facility during the last two years. The intravenous amino acids, vitamins, and mineral therapy appears to augment the dopamine and serotonin levels while the body begins to return to better handling oral nutrients and neurotransmitter homeostasis.

This study has been implemented to determine the efficacy of intravenous amino acids to reduce withdrawal and craving from substance abuse.

Methodology

Nine subjects were picked from phone in volunteers from a local Denver newspaper add (Exhibit 1).

Inclusion into the study are individuals who are between the ages of 18 and 50 years old, in good health, not court ordered and who desire to stop their substance abuse, but to date, are unable to do so. Methadone or a history of psychiatric hospitalize subjects are excluded from this study. All subjects will undergo a history and physical exam and a doctor will be present at all times. Initials will be used for publishing purposes only and strict confidentiality will be observed of all subjects.

The treatment subjects will undergo 10 sessions (Monday through Friday) of a multi amino acid, vitamin and mineral solution in a 250cc ½ NS bag group or a placebo group of Vitamins (B2, B12 and Folate) in a 250cc ½ NS bag with matching color and volume. All subjects will undergo drug testing for their addiction including random breath and/or urine drug tests.

If you smoke, you will be asked to keep track of the number of cigarettes smoked daily.

To be entered into the research group each individual must meet the requirement of the Diagnostic and Statistical Manual of Mental Disorders TR (DSM-IV TR) for an Axis-I drug dependence.

Axis-I 303.90 Alcohol Dependence

Axis-I 304.40 Amphetamine Dependence Including Methamphetamine

Axis-I 304.30 Cannabis Dependence

Axis-I 304.20 Cocaine Dependence

Axis-I 305.10 Nicotine Dependence

Axis-I 304.00 Opioid Dependence

Axis-I 304.90 Polysubstance-related Disorder

Other axis-I substance dependence disorders will be assessed on a case-by-case basis.

The research subjects will be placed randomly into two equal groups A and B.

The control-or placebo-group will receive an intravenous solution of 250 cc of a ½ normal saline bag with B2, B12 and folate to give the distinctive color to the bags.

The experimental group will be given an intravenous solution consisting of a patented formula titled TGGRS Treatment (Third Generation Genetic Repair System). The Tigers Treatment consists of multi amino acids, vitamins and mineral solution drip over a 1 & 2-hour period for 10 sessions. All subjects will be randomly be monitored by blowing a B.A.C. or urine drug tests. A questionnaire will also be required to rate their craving and anxiety symptoms each session. Specific cravings will be rated from a zero (0)-indicating no craving or withdrawal, to a ten (10)-indicating maximum craving or withdrawal symptoms.

The intravenous bags will be marked “Group A” and “Group B” and will be made by a local compounding pharmacist. He will have no contact with the subjects. Heart rate, blood pressure and level of subject mental status will be conducted before each session. During the study, all subjects will be asked to eliminate or cut back on their alcohol or drug consumption but at any time may voluntary return to their pre-study consumption level, or be asked to by the doctor, if sever withdrawal symptoms occur. Failure to participate in 90% of the study will be grounds for dismissal. The people involved in administering the I.V. and monitoring the people will not know which bags contain the amino acids and which contain the placebo. At the end of 10-days the pharmacists will expose which group was the experimental group and which group was the placebo group-A or B, respectively. At that time the experimental and the placebo groups will undergo a daily debriefing and questionnaire rating their withdrawal symptom success and anti-craving level.

At the end of 10 sessions, the treatment group will be given 5 additional treatments of the same solution with D-phenylalanine added. Afterwards, the placebo group will get the treatment solution for 5 sessions followed by 5 session with D-phenylalanine added. All subjects at the end of their intravenous sessions will be debriefed and given the opportunity to take a one months worth of a similar oral based formula for maintenance efficacy.

Results

To stay sober, the war on addiction has many battlefronts to concour from dealing with initial withdrawals and craving to handling family and friend enablers, denial, stress, temptation and faith that we can overcome the disease that seals the heart, soul and life of mankind.

From Jan 21 until Feb 17th nine volunteers under took a major step to sobriety by introducing nutrition building blocks of neurotransmitters by intravenous means to battle withdrawal and cravings aspects. Only one individual had no response to our amino acids vitamin and mineral cocktail and continue daily drinking with no perceived change in anxiety and craving. All others expressed a significant response from moderate to profound anti-craving benefits by the end of the study.

The A group (RH, RY, KM, RA) received vitamins for the first 10 sessions, and although noticed a slight reduction in craving and anxiety, RY, KM, KA continued to drink. RH had marijuana addiction problems and throughout the study he did not use. The B group (RM, DR, RD, DB, JD) received the therapeutic formula less the D isomer of phenylalanine. They all continued drinking and showed no significant change in craving and anxiety. The A group noticed no significant change as well to 5 days of the therapeutic formula minus the D isomer. It wasn’t until the last 5 days in both groups that a significant response in drinking reduction in sobriety along with cravings and anxiety reduction occurring.

The D isomer of phenylalanine appears to be a crucial component in withdrawal and craving issues. Addition to alcohol and drugs is caused by an imbalance or defiency of neurotransmitter activity in a cascade mode. Per Dr Blum serotonin releases enkephalin in the hypothalamus and enkephalin inhibits the release of GABA in the substantia nigra. The inhibition of GABA permits the release of dopamine in both the nucleus accumbens and the hippocampus.

Apparently up regulation of serotonin by tryptofan is not enough to release sufficient enkephalins to have an impact on up regulating dopamine despite direct stimulation of L-phenylalanine and L-tyrosine on increased dopamine production. The D form of phenylalanine, which inhibits enkephalin, appears paramount in the cascade theory and therefore causing substantial anxiety and craving reduction. Enkephlins are nature’s natural painkillers and a reduction in pain appears critical to suppressing withdrawal and craving symptoms as well as balancing neurotransmitters. This study supports the 86% recovery rate in retrospective review of the current intravenous amino acid (TGGRS solution) being conducted at Excel treatment and recovery program. However, future clinical trials with genetic testing and greater numbers coupled with a variety of addictions would better support statistical efficacy of intravenous amino acid supplementation. In addition, why 10 to 15 percent of the population fail this program possibly could be cause from a yet unknown genetic pathway of metabolism with nationality possibly playing a role in this failure rate.

Conclusion

The TGGRS intravenous amino acid program in its current formula had statistical efficacy in nine patient’s ability to handle their craving and anxiety perception and their ability to withdraw from alcohol. The D-phenylalanine isomer appears to be an essential ingredient to this formula. Together with education and counselling and nutrition, intravenous amino acid supplementation will prove to be a powerful tool in initially combating the evil grasp of addiction in today’s society.

How Online Poker Secret Algorithms Work

Many online poker players look for an edge in winning cash for their account by implementing strategies they know that usually work in live games. However, as many of these players have found, those strategies often do not work online. There are two good reasons why live Texas holdem strategies fail when it comes to online poker, the online poker secret algorithms and the inability of a player to adapt his game.

The Online Poker Secret Algorithms

Many will scoff at the fact that poker sites use any type of secret poker algorithms to control the outcome or play in a game, and every major poker site will deny such codes even exist. Yet, the undeniable proof is in the plausible deniability of the sites themselves in addition to the constant poker bad beats witnessed online.

Most players are oblivious to the fact that additional software programs are running on the poker sites servers that will perpetrate action inducing hands and bad beats. In fact, many players will get mad, go on tilt and blame the donkeys they are playing against, when in reality; it is the secret algorithms that poker sites use.

Those algorithms are actually intended to stop cheating and collusion by forcing wins and losses in a more ecumenical manner very much unlike a live game. In other words, oftentimes when a bad beat occurs, it is a result of a highly unlikely hand and major underdog, beating the better hand on the river.

Adapting Your Play to Win Online

In order to beat the online poker secret algorithms, it is necessary to adapt your Texas Holdem game to a different style when playing online. Although you may have used many advanced strategies in your live play to win pots, you will soon realize that these same strategies are less effectual in an online game.

One of the major changes necessary to adapt your game is avoiding the pitfalls of trying to push players off a draw. The reason is that the action inducing algorithms in the poker sites software will force a draw heavy board that actually gets there more than 20% of the time it normally would in a live game (for example, a flush draw will make the flush 18%-20% more often online, and straight draws occur 15% more often).

Because you are up against a computer program that delivers the cards and effectively ignores the real statistics of the game, in addition to inexperienced players who will chase their draws, you must avoid a whole lot more landmines when you play Texas holdem online.

The Cosmetic Corporate Governance – Will Companies Learn Lessons From the Global Financial Crisis!

The impact of the crises started to diminish. Still, all key players, including top executives, regulators and investors, have much to learn from the global financial failures. The Organisation for Economic Co-operation and Development (OECD) Steering group has issued a report entitled Corporate Governance Lessons from the Financial Crisis. This Report concludes that among major contributors to the financial crisis are failures and weaknesses in corporate governance arrangements. When they were put to a test, corporate governance routines did not serve their purpose to safeguard against excessive risk taking in a number of financial services institutions.

Other key contributors to the global financial crises include failures in transparency, failures in lending standards; failures in prudential standards; failures in risk-management.

As to the remuneration of top executives, the real problem was not the amount they receive; it is how companies pay them. The bad bonus culture encourages a short-term thinking: hit as many deals as you can this year and get a larger bonus! That approach pushed executives to focus their attention to achieving short term objectives at the expense of sustainable growth objectives.

Most financial institutions link compensation to quarterly performance, encouraging short-term gambles. When the bets win, executives get the rewards, but when the bets sour, as they have in the latest financial crunch, the executives who took the risks do not have to return their fat-cat bonuses. The executives were, in most cases, no longer gambling with their own net worth. It was the shareholders who took the hit. Thus the executive greed acted as fuel thrown on the fires of and contributed to the blazing global financial crisis. The right approach if we are going to keep the financial system from being misused by top executives’ greed again is to maintain a partnership between the top executives and have their net worth tied to the organisations’ well-being. As a result, they would be cautious about taking big risks and discourage the malpractice of running after short terms gains. Also, we need to replace bonuses with better, longer-term compensation such as deferred cash pay and restricted stock.

The directors of the troubled institutions appear to have provided only the thin-surfaced supervision to control the greed of top executives. The boards of the collapsed firms carry the full responsibility. Each month they see the numbers. They are also responsible for compliance with regulations. And they set the remunerations packages for the top executives. However the troubled firms just ticked the boxes for good corporate governance in their annual reports. In other words, there organisations presented an obvious example of the cosmetic corporate governance to fool different stockholders including investors, rating agencies and regulators!

The current global financial crisis has shed light on how poor risk management could lead to catastrophic results. The risk management systems have failed in many cases due to corporate governance procedures rather than the inadequacy of computer models alone.

With the advent of new products such as sophisticated derivatives and certificate of deposits, they posed unknown risks. Risk management may not have been up to the task since many of the standard quantitative models and users of these models regularly misjudged the systematic nature of risks. To some extent this was due to product complexity and over-reliance on quantitative analysis. Sadly, many risk evaluations were wrong including those provided by rating agencies.

The directors of the collapsed financial institutions should have better understanding of the risk implication at the time of taking decisions related to sophisticated products such as derivatives. The reality is many board members had inadequate knowledge on the sophisticated new products and likely were embarrassed to show that they lack the adequate knowledge! Here where directors’ education and orientation fails as best corporate governance best practice. On going education is important to ensure that the directors are familiar with all aspects of the company’s affairs with a particular focus on risks. Each director must receive customized orientation programs in areas where heshe lack adequate knowledge in order to be able to effectively undertake the fiduciary oversight role.

Finally, the concept that in bad times companies would be more interested in supporting their profitability and accordingly will not have time for corporate governance is irrational. The integrity cannot be compromised because corporate governance is not seasonal – it is for all times and must be embedded in senior corporate executives and directors. Companies must not put corporate governance on the shelf in bad times. It is like a muscle, must be exercised or it will atrophy

Warriors in Burning Crusade

The role of the warrior changed significantly in Burning Crusade when compared with vanilla WoW; this article is written to illustrate the mentality and the environment of players which played warriors during Burning Crusade felt.

Warriors have always played a very dominant role in World of Warcraft, although in Burning Crusade classes such as Paladins and Druids were buffed heavily in their respective tanking specializations, with their traditional Sword and Board tanking style warriors still shined as the premium Main Tank for any raid. It is always hard to share the pedestal with others, in vanilla WoW warriors were the only real tank for any raid encounter – making them feel threatened in this aspect during the release of Burning Crusade. However, blizzard’s love for warriors continued to grow and although Paladins and Druid tanks were used, they were mainly placed in roles of Area of Effect Tanking (AoE) and Off Tanking (OT) with Warriors still tanking the top spot for tanking raid bosses due to their superior damage mitigation and rage mechanic.

The skills used by warriors tanks were almost identical to that of vanilla WoW (heroic strike, revenge, shield block, sunder armor), and although blizzard did implement many encounters which required AoE tanking, they chose not to give warriors much utility for AoE tanking until very late in the Burning Crusade expansion (possibly to give other classes a chance to shine in another tanking aspect). This caused considerable distaste for the warrior class, whereby many players preferred to use Paladins or Druids to tank heroics as warriored tank runs generally took much longer due to their limited AoE capabilities and the need to bring along crowd-control (CC) classes such as mages, warlocks, rogues in order to make up for this deficit.

Damage Per Second (DPS) warriors faced a vastly different environment from vanilla WoW, Arms specialization was now strictly for PvP purposes and Fury (one hand duel -wield) for PvE. Arguably, warriors have, and possibly always will be the most gear dependent class due to the rage mechanism. Due to this, highly geared fury wars often were able to top charts for many boss fights in Black Temple and Sunwell. However, because of this same rage mechanic undergeared warriors often were left to “bite the dust” of other classes as blizzard was unable to scale warriors in such a way which would allow undergeared players to be competitive without overgeared players completely overwhelming other classes.

Does Everything Depend on Luck in a Bingo Game?

The bingo is an online casino gambling game. The rules and regulations are very easy for a bingo game. This makes a player of bingo earn a fortune. There are no easy ways and means to enhance your winnings in bingo game and it purely depends on luck. However, some points need to be considered for winning a game. In Bingo game, the player cannot have any control on the outcome of the game, so women generally prefer this. Men play blackjack and pokers. The men like to gamble with game where a option of control is felt. The cards are drawn at random and will not be repeated. Online bingos are preferred as they give ample privacy to a player and make the player feel at ease.

Game Strategy

The procedure of the bingo game is very simple and one needs to prepare before the start of the game. The start of the game is with a purchase of a card marked with letters in the form B, I, N, G, O on the face of the top column. There will be another set of numbers in another column. The player is required to mark the series of number once host announces it. You must attain a desired pattern on the bingo card with the markings.

Bingo strategy is an important aspect in understanding how bingo is played. Bingo cards come in two different forms, a hard permanent bingo cards and a disposable paper sheets. The numbers are preprinted and contain 24 of them. The center of the bingo card has a free spot. The bingo blotter, a special marker used to mark the paper bingo cards and at the end of each bingo game they are thrown away. In case of permanent bingo cards, they have little shutters or windows, which can move smoothly over top of a number when it is called. They are then reused by removing the shutters or windows. In permanent bingo cards, the number remains same where as number keeps on changing in disposable bingo card. The players are offered chances to play more than one bingo game at a time, but for an additional cost.

Game Patterns

Bingo can be played in many patterns. It could be in a vertical direction, in horizontal direction or even diagonally. Other forms of pattern include four corners of the board or even shape like T, etc. When all the numbers on their bingo card have been selected, bingo player wins. This game is called a coverall bingo game.

Seventy-five bingo balls are encased and spun. At the start, the bingo caller announces the pattern selected for each game. Once the ball is selected, it is displayed electronically to see the numbers and these are removed to avoid further selection. Now computers are available for ball selection.

Winning at Bingo

The chances of winning the game are based on luck and no element can influence or predict the outcome of the game. Bingo games are played for fun, as no decisions need to be made. However, there are some essential tips that give a better chance to win the game. Playing one card at a time is suggested and banging should be avoided while dabbing. A paper card with lower number should be selected. This has more chance of getting the numbers closer together. In Overall games, it is suggested that you come out early and get the first set issued. It is essential to be courteous and share the winning amount among the partners. Ideally, the chances of winning are when you play with fewer members. Some even record their games if they are trying out some special games. It is simple to dab.

Avoid interruptions while playing. Kids should be kept away, they may be taken to kids corner or even let them stay-at-home. Concentrate on the numbers that are read out. It is advisable to avoid night games, as there are chances that you miss the numbers already called. Limit the amount spending on the game. Buying cards to impress others should be avoided.

Cyber Bingo Game Strategy

Cyber bingo is a game, which can fetch you a good fortune. Like other bingo, the cyber bingo too depends on luck. However, to improve your chances of winning online it is required that you follow certain rules.

It is wiser to avoid playing on busy online bingo sites. Chances are that you have to compete against several bingo players. Internet sites that have chat rooms should be chosen. Play bingo games at website, which offers the best deposit bonuses. A trusted cyber casino should be considered as only these casinos give the full amount payment after you win a game.

Chat with other fellow players on the cards they play. You may increase the card numbers to revert victory to your side. A regular player may be able to identify the number of players in the particular game. Playing at sites where the number of players is balanced gives more chance to win the game. Playing at odd hours let you have a chance to win. Avoid too many cards in large jackpot bingo games. Some sites even offer free cash if you play or refer the site to friends. A casino that offers hundred percent deposit bonuses should be preferred.

Machines for Bingo

The new generation bingo game now operates with machines that are eventually same as a slot machine. The machines are legal and carry names such as “Triple Threat Bingo”. Operation of this type machine is easy and simple. They have colorful lights and drums spinning with pictures of fruits or even diamonds. A player drops a coin and press the button. If one gets same line up, the player wins. These machines also have the advantage to track a bingo game and even print tickets for winners to reimburse their winning amount.